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Results from the Global Lung Function Initiative

  1. The study performed by the Global Lung Function Initiative is based on a very large and representative population sample.
  2. The recommendations have been endorsed by 6 large international respiratory societies:
    • European Respiratory Society,
    • American Thoracic Society,
    • Australian and New Zealand Society of Respiratory Science,
    • Asian Pacific Society for Respirology,
    • Thoracic Society of Australia and New Zealand, and
    • the American College of Chest Physicians.
  3. GLI-2012 provides regression equations for spirometry for the 3-95 year age range, and for a number of ethnic groups.
  4. The age dependence of the lower limit of normal has been accounted for.
  5. Z-scores offer the opportunity to interpret test results independent of age, height, sex and ethnic group.
  6. Adoption of the Quanjer GLI-2012 equations for spirometry will lead to minor changes in the prevalence rate of airway obstruction in clinical populations.
  7. The use of percent of predicted values leads to an unacceptable age bias and needs to be replaced by the use of z-scores.
  8. The GOLD doctrine does not respect the clinically valid lower limit of normal and leads to considerable under and over diagnosis of airway obstruction.
  9. Adopting the Quanjer GLI-2012 equations will lead to an increase in the prevalence rate of a ‘restrictive pattern’ compared to ECSC; the clinical guideline is: “treat the patient, not the data”.

Dowload this information about the GLI project as a pdf file (4.69 MB)

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