Results from the Global Lung Function Initiative
- The study performed by the Global Lung Function Initiative is based on a very large and representative population sample.
- The recommendations have been endorsed by 6 large international respiratory societies:
• European Respiratory Society,
• American Thoracic Society,
• Australian and New Zealand Society of Respiratory Science,
• Asian Pacific Society for Respirology,
• Thoracic Society of Australia and New Zealand, and
• the American College of Chest Physicians.
- GLI-2012 provides regression equations for spirometry for the 3-95 year age range, and for a number of ethnic groups.
- The age dependence of the lower limit of normal has been accounted for.
- Z-scores offer the opportunity to interpret test results independent of age, height, sex and ethnic group.
- Adoption of the Quanjer GLI-2012 equations for spirometry will lead to minor changes in the prevalence rate of airway obstruction in clinical populations.
- The use of percent of predicted values leads to an unacceptable age bias and needs to be replaced by the use of z-scores.
- The GOLD doctrine does not respect the clinically valid lower limit of normal and leads to considerable under and over diagnosis of airway obstruction.
- Adopting the Quanjer GLI-2012 equations will lead to an increase in the prevalence rate of a ‘restrictive pattern’ compared to ECSC; the clinical guideline is: “treat the patient, not the data”.
Dowload this information about the GLI project as a pdf file (4.69 MB)